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Cynomolgus TNFR1/CD120a/TNFRSF1A Protein 5065

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu30-Thr211
SKU: 5065parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A0A7N9CVF2

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.

molecular weight

The protein has a predicted MW of 21.62 kDa. Due to glycosylation, the protein migrates to 32-42 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus TNFR1/CD120a/TNFRSF1A Protein 5065

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
Protein names
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (Tumor necrosis factor receptor type I) (p55) (p60)
Gene names
TNFRSF1A,TNFRSF1A
Mass
9541Da
Subellular location
Cell membrane ; Single-pass type I membrane protein. Golgi apparatus membrane ; Single-pass type I membrane protein. Membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: A0A7N9CVF2
The UniProt Consortium

SPR with Cynomolgus TNFR1/CD120a/TNFRSF1A Protein
Cynomolgus TNFR1, His Tag immobilized on CM5 Chip can bind Cynomolgus TNF alpha, His Tag with an affinity constant of 0.23 nM as determined in SPR assay (Biacore T200).
ELISA with Cynomolgus TNFR1/CD120a/TNFRSF1A Protein
Immobilized Cynomolgus TNFR1, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human TNF alpha, His Tag with the EC50 of 17.2ng/ml determined by ELISA (QC Test).
HPLC of Cynomolgus TNFR1/CD120a/TNFRSF1A Protein
The purity of Cynomolgus TNFR1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus TNFR1/CD120a/TNFRSF1A Protein
Cynomolgus TNFR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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