SDS-PAGE gel of Cynomolgus/Rhesus macaque B2M/beta 2-Microglobulin Prot 4233

Cynomolgus/Rhesus macaque B2M/beta 2-Microglobulin Protein 4233

$195.00 – $650.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Ile21-Met119

SKU: 4233parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q8SPW0
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
molecular weight	The protein has a predicted MW of 12.7 kDa. Due to glycosylation, the protein migrates to 13-15 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus/Rhesus macaque B2M/beta 2-Microglobulin Protein 4233

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
Protein names Beta-2-microglobulin
Gene names B2M,B2M QtsA-15719
Protein family Beta-2-microglobulin family
Mass 13567Da
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
Subellular location Secreted .
Structure Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
Target Relevance information above includes information from UniProt accession: Q8SPW0
The UniProt Consortium

Data

HPLC of Cynomolgus/Rhesus macaque B2M/beta 2-Microglobulin Protein

The purity of Cynomolgus/Rhesus macaque B2M is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus/Rhesus macaque B2M/beta 2-Microglobulin Prot

Cynomolgus/Rhesus macaque B2M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.