ELISA with Cynomolgus/Rhesus macaque AMHRII Protein 3440

Cynomolgus/Rhesus macaque AMHRII Protein 3440

$675.00 – $2,250.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Pro18-Ser144

SKU: 3440parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_001105261
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls.
molecular weight	The protein has a predicted MW of 40.24 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per ug by the LAL method.

Cynomolgus/Rhesus macaque AMHRII Protein 3440

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The aim of the current study was to explore whether anti-MÃ¼llerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls.
Protein names Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
Protein family Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfam
Mass 62750Da
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30;
Subellular location Membrane; Single-pass type I membrane protein.
Structure Interacts with type I receptor ACVR1. {ECO:0000269\|PubMed:17911401}.
Target Relevance information above includes information from UniProt accession: Q16671
The UniProt Consortium

Data

ELISA with Cynomolgus/Rhesus macaque AMHRII Protein

Immobilized Cynomolgus/Rhesus macaque AMHRII, hFc Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Anti-AMHRII Antibody, hFc Tag with the EC50 of 85.7ng/ml determined by ELISA.

HPLC of Cynomolgus/Rhesus macaque AMHRII Protein

The purity of Cynomolgus/Rhesus macaque AMHRII is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus/Rhesus macaque AMHRII Protein

Cynomolgus/Rhesus macaque AMHRII on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.