Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | XP_045246087 |
express system | HEK293 |
product tag | N-hFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. |
molecular weight | The protein has a predicted MW of 34.65 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus LY6G6D Protein 2063
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Asn20-Ser104
Cynomolgus LY6G6D Protein 2063
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. |
Protein names Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein) |
Gene names LY6G6D,LY6G6D C6orf23 G6D MEGT1 NG25 |
Mass 9606Da |
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor. Cell projection, filopodium . |
Tissues Expressed in the adult lung, and in fetal liver, lung, kidney, brain and spleen. |
Structure Homodimer. |
Post-translational modification O-glycosylated. |
Target Relevance information above includes information from UniProt accession: O95868 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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