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Cynomolgus LY6G6D Protein 2063

$300.00$1,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Asn20-Ser104
SKU: 2063parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

XP_045246087

express system

HEK293

product tag

N-hFc

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.

molecular weight

The protein has a predicted MW of 34.65 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus LY6G6D Protein 2063

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Protein names
Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein)
Gene names
LY6G6D,LY6G6D C6orf23 G6D MEGT1 NG25
Mass
9606Da
Subellular location
Cell membrane ; Lipid-anchor, GPI-anchor. Cell projection, filopodium .
Tissues
Expressed in the adult lung, and in fetal liver, lung, kidney, brain and spleen.
Structure
Homodimer.
Post-translational modification
O-glycosylated.
Target Relevance information above includes information from UniProt accession: O95868
The UniProt Consortium

ELISA with Cynomolgus LY6G6D Protein
Immobilized Cynomolgus LY6G6D, hFc Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Anti-LY6G6D Antibody, hFc Tag with the EC50 of 12.2ng/ml determined by ELISA.
HPLC of Cynomolgus LY6G6D Protein
The purity of Cynomolgus LY6G6D is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus LY6G6D Protein
Cynomolgus LY6G6D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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