Cynomolgus IL-33 Protein 3958

$345.00 – $1,150.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: His109-Ile270

SKU: 3958parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	A0A2K5W3I1
express system	HEK293
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE
background	Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
molecular weight	The protein has a predicted MW of 19.2 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus IL-33 Protein 3958

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
Protein names Interleukin-33
Gene names IL33,IL33
Protein family IL-1 family
Mass 30458Da
Function FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation. {ECO:0000256\|ARBA:ARBA00045203}.
Subellular location SUBCELLULAR LOCATION: Chromosome {ECO:0000256\|ARBA:ARBA00004286}. Cytoplasmic vesicle, secretory vesicle {ECO:0000256\|ARBA:ARBA00004398}. Nucleus {ECO:0000256\|ARBA:ARBA00004123}. Secreted {ECO:0000256\|ARBA:ARBA00004613}.
Structure SUBUNIT: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. {ECO:0000256\|ARBA:ARBA00046367}.
Target Relevance information above includes information from UniProt accession: A0A2K5W3I1
The UniProt Consortium

Data

Human IL-1RL1, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-33, His Tag with an affinity constant of 46.85 nM as determined in SPR assay (Biacore T200).

SDS-PAGE gel of Cynomolgus IL-33 Protein

Cynomolgus IL-33 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.