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Cynomolgus IL-18BP Protein 2735

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Thr28-Pro207
SKU: 2735parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A0A2K5UDJ4

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE

background

Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.

molecular weight

The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 35-65 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus IL-18BP Protein 2735

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Protein names
Interleukin-18-binding protein
Mass
9541Da
Target Relevance information above includes information from UniProt accession: A0A2K5UDJ4
The UniProt Consortium

ELISA with Cynomolgus IL-18BP Protein
Immobilized Human IL-18, No Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Cynomolgus IL-18BP, His Tag with the EC50 of 3.0ng/ml determined by ELISA.
SDS-PAGE gel of Cynomolgus IL-18BP Protein
Cynomolgus IL-18BP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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