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Cynomolgus IL-17A/CTLA-8 Protein 4586

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gly24-Ala155
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

XP_005552816

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 92% as determined by HPLC

background

Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.

molecular weight

The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 26-32 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus IL-17A/CTLA-8 Protein 4586

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
No information
target relevance

Data

ELISA with Cynomolgus IL-17A/CTLA-8 Protein
Immobilized Cynomolgus IL-17A, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-IL-17A Antibody, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA.
HPLC of Cynomolgus IL-17A/CTLA-8 Protein
The purity of Cynomolgus IL-17A is greater than 92% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus IL-17A/CTLA-8 Protein
Cynomolgus IL-17A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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