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Cynomolgus IL-10 R alpha Protein 2793

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: His22-Asn233
SKU: 2793parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A0A2K5WJ66

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.

molecular weight

The protein has a predicted MW of 25.34 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus IL-10 R alpha Protein 2793

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.
Protein names
Interleukin 10 receptor subunit alpha
Gene names
IL10RA,IL10RA
Mass
9541Da
Target Relevance information above includes information from UniProt accession: A0A2K5WJ66
The UniProt Consortium

SPR with Cynomolgus IL-10 R alpha Protein
Cynomolgus IL-10 R alpha, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-10, His Tag with an affinity constant of 0.93 nM as determined in SPR assay (Biacore T200).
ELISA with Cynomolgus IL-10 R alpha Protein
Immobilized Human IL-10, No Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Cynomolgus IL-10 R alpha, His Tag with the EC50 of 35.0ng/ml determined by ELISA (QC Test).
HPLC of Cynomolgus IL-10 R alpha Protein
The purity of Cynomolgus IL-10 R alpha is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus IL-10 R alpha Protein
Cynomolgus IL-10 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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