Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | G7P9I7 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. |
molecular weight | The protein has a predicted MW of 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus IGF1R/CD221 Protein 5056
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Glu31-Asn908
Cynomolgus IGF1R/CD221 Protein 5056
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. |
Protein names Tyrosine-protein kinase receptor (EC 2.7.10.1) |
Gene names IGF1R,IGF1R |
Protein family Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily |
Mass 9541Da |
Catalytic activity BINDING 985; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1009; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-ProRule:PRU10141"; BINDING 1056..1062; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1115..1116; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1129; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2" |
Subellular location Membrane ; Single-pass type I membrane protein . |
Target Relevance information above includes information from UniProt accession: G7P9I7 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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