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Cynomolgus IGF1R/CD221 Protein 5056

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Glu31-Asn908
SKU: 5056parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

G7P9I7

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

molecular weight

The protein has a predicted MW of 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus IGF1R/CD221 Protein 5056

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Protein names
Tyrosine-protein kinase receptor (EC 2.7.10.1)
Gene names
IGF1R,IGF1R
Protein family
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Mass
9541Da
Catalytic activity
BINDING 985; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1009; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-ProRule:PRU10141"; BINDING 1056..1062; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1115..1116; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"; BINDING 1129; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
Subellular location
Membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: G7P9I7
The UniProt Consortium

ELISA with Cynomolgus IGF1R/CD221 Protein
Immobilized Cynomolgus IGF1R, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-IGF1R Antibody, hFc Tag with the EC50 of 5.7ng/ml determined by ELISA.
HPLC of Cynomolgus IGF1R/CD221 Protein
The purity of Cynomolgus IGF1R is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus IGF1R/CD221 Protein
Cynomolgus IGF1R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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