Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | A0A2K5WVL1 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein. |
molecular weight | The protein has a predicted MW of 50.30 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus HPX Protein 2787
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Asn24-Tyr462
Cynomolgus HPX Protein 2787
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein. |
Protein names Hemopexin |
Protein family Hemopexin family |
Mass 9541Da |
Function Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. |
Catalytic activity BINDING 79; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="1"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000256|PIRSR:PIRSR002551-2"; BINDING 150; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="1"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000256|PIRSR:PIRSR002551-2"; BINDING 236; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="2"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000256|PIRSR:PIRSR002551-2"; BINDING 293; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="2"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000256|PIRSR:PIRSR002551-2" |
Subellular location Secreted . |
Target Relevance information above includes information from UniProt accession: A0A2K5WVL1 |
The UniProt Consortium |
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The purity of Cynomolgus HPX is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus HPX on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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