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Cynomolgus Fc gamma RIIB Protein 3323

$270.00$900.00

Summary

  • Expression: HEK293
  • Binding assay: Yes (SPR)
  • Amino Acid Range: Ala46-Pro224
SKU: 3323parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q8SPW3

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens.

molecular weight

The protein has a predicted MW of 21 kDa. Due to glycosylation, the protein migrates to 33-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus Fc gamma RIIB Protein 3323

Data

SPR with Cynomolgus Fc gamma RIIB Protein
Trastuzumab captured on CM5 Chip via Protein A can bind Cynomolgus Fc gamma RIIB, His Tag with an affinity constant of 2.72 µM as determined in SPR assay (Biacore T200).
HPLC of Cynomolgus Fc gamma RIIB Protein
The purity of Cynomolgus Fc gamma RIIB is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus Fc gamma RIIB Protein
Cynomolgus Fc gamma RIIB on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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