Cynomolgus CDH17/Cadherin 17 Protein 2163

$345.00 – $1,150.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Gln23-Thr784

SKU: 2163parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_005563762.2
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
molecular weight	The protein has a predicted MW of 85.57 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1 EU per μg by the LAL method.

Cynomolgus CDH17/Cadherin 17 Protein 2163

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Protein names Cadherin 17
Gene names CDH17,CDH17
Mass 9544Da
Target Relevance information above includes information from UniProt accession: A0A1D5R2B4
The UniProt Consortium

ELISA with Cynomolgus CDH17/Cadherin 17 Protein

Immobilized Cynomolgus CDH17, His Tag at 0.5 µg/ml (100 µl/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5 ng/ml determined by ELISA.

HPLC of Cynomolgus CDH17/Cadherin 17 Protein

The purity of Cynomolgus CDH17 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus CDH17/Cadherin 17 Protein

Cynomolgus CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.