ELISA with Cynomolgus CD96/TACTILE Protein 3076

Cynomolgus CD96/TACTILE Protein 3076

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Val22-Gly502

SKU: 3076parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	A0A2K5TWV6
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.
molecular weight	The protein has a predicted MW of 54.27 kDa. Due to glycosylation, the protein migrates to 80-130 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus CD96/TACTILE Protein 3076

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.
Protein names CD96 molecule
Gene names CD96,CD96
Mass 9541Da
Target Relevance information above includes information from UniProt accession: A0A2K5TWV6
The UniProt Consortium

Data

ELISA with Cynomolgus CD96/TACTILE Protein

Immobilized Cynomolgus CD96, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.93µg/ml determined by ELISA.

The purity of Cynomolgus CD96 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus CD96/TACTILE Protein

Cynomolgus CD96 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.