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Cynomolgus CD228/MFI2 Protein 2195

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Gly20-Cys709
SKU: 2195parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

XP_015300315.2

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Melanotransferrin is typically overexpressed in melanoma cells compared to other cell types – including cancer cells – and is efficiently sorted and secreted with nanovesicles, or so-called exosomes, due to its membrane-anchoring by a glycosylphosphatidylinositol. Melanotransferrin is exposed on the surface of exosomes and is accessible for antibody recognition.

molecular weight

The protein has a predicted MW of 76.39 kDa. Due to glycosylation, the protein migrates to 77-90 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus CD228/MFI2 Protein 2195

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Melanotransferrin is typically overexpressed in melanoma cells compared to other cell types - including cancer cells - and is efficiently sorted and secreted with nanovesicles, or so-called exosomes, due to its membrane-anchoring by a glycosylphosphatidylinositol. Melanotransferrin is exposed on the surface of exosomes and is accessible for antibody recognition.
Protein names
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Protein family
Transferrin family
Mass
80215Da
Function
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. {ECO:0000269|PubMed:7556058}.
Subellular location
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
Tissues
Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
Target Relevance information above includes information from UniProt accession: P08582
The UniProt Consortium

HPLC of Cynomolgus CD228/MFI2 Protein
The purity of Cynomolgus CD228 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus CD228/MFI2 Protein
Cynomolgus CD228 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmidtitleauthorscitation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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