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Cynomolgus c-MPL/Thrombopoietin R Protein 2758

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln22-Thr489
SKU: 2758parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A0A2K5UGC7

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE

background

The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.

molecular weight

The protein has a predicted MW of 53.48 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus c-MPL/Thrombopoietin R Protein 2758

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
Protein names
MPL proto-oncogene, thrombopoietin receptor
Gene names
MPL,MPL
Protein family
Type I cytokine receptor family, Type 1 subfamily
Mass
9541Da
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: A0A2K5UGC7
The UniProt Consortium

ELISA with Cynomolgus c-MPL/Thrombopoietin R Protein
Immobilized Cynomolgus c-MPL, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.
SDS-PAGE gel of Cynomolgus c-MPL/Thrombopoietin R Protein
Cynomolgus c-MPL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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