Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | XP_005582755 |
express system | HEK293 |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
background | ASGR1 is a liver-specific surface marker that is exclusively expressed in liver and mediates internalization and lysosomal degradation of blood asialoglycoproteins. |
molecular weight | The protein has a predicted MW of 27.43 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus ASGR1 Protein 2157
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Gln62-Leu291
Cynomolgus ASGR1 Protein 2157
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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ASGR1 is a liver-specific surface marker that is exclusively expressed in liver and mediates internalization and lysosomal degradation of blood asialoglycoproteins. |
Protein names Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) |
Gene names ASGR1,ASGR1 CLEC4H1 |
Mass 9606Da |
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
Subellular location [Isoform H1a]: Membrane; Single-pass type II membrane protein.; [Isoform H1b]: Secreted . |
Tissues Expressed exclusively in hepatic parenchymal cells. |
Structure Interacts with LASS2.; (Microbial infection) Interacts with hepatitis E virus capsid protein ORF2. |
Post-translational modification Phosphorylated on a cytoplasmic Ser residue. |
Target Relevance information above includes information from UniProt accession: P07306 |
The UniProt Consortium |
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The purity of Cynomolgus ASGR1 is greater than 90% as determined by SEC-HPLC. |
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Cynomolgus ASGR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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