Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | A0A2K5U7U0 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. |
molecular weight | The protein has a predicted MW of 67.53 kDa. Due to glycosylation, the protein migrates to 68-75 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus AFP Protein 2765
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Arg19-Val609
Cynomolgus AFP Protein 2765
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. |
Protein names Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) |
Gene names AFP,AFP |
Mass 9541Da |
Catalytic activity BINDING 273; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="1"; /evidence="ECO:0000256|PIRSR:PIRSR002520-1"; BINDING 273; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000256|PIRSR:PIRSR002520-1" |
Subellular location Secreted . |
Target Relevance information above includes information from UniProt accession: A0A2K5U7U0 |
The UniProt Consortium |
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The purity of Cynomolgus AFP is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus AFP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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