Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | A0A8C0M6T8 |
express system | Yeast |
product tag | N-His |
purity | > 90% as determined by Tris-Bis PAGE |
background | Platelet-derived growth factors (PDGFs) may play an important role in the development of atherosclerosis acting as chemoattractants and mitogens for vascular smooth muscle cells and macrophages. PDGFA, the most known member of PDGF family, plays a crucial role in occurrence and progression of different tumors. |
molecular weight | The protein has a predicted MW of 13.62 kDa. Due to glycosylation, the protein migrates to 15-20 kDa and 35-45 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Canine PDGFA Protein 2379
$345.00 – $1,150.00
Summary
- Expression: Yeast
- Active: Yes (cell based assay)
- Amino Acid Range: Ser87-Arg196
Canine PDGFA Protein 2379
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Platelet-derived growth factors (PDGFs) may play an important role in the development of atherosclerosis acting as chemoattractants and mitogens for vascular smooth muscle cells and macrophages. PDGFA, the most known member of PDGF family, plays a crucial role in occurrence and progression of different tumors. |
Protein names Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) |
Gene names PDGFA,PDGFA |
Protein family PDGF/VEGF growth factor family |
Mass 9615Da |
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. |
Structure Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. |
Target Relevance information above includes information from UniProt accession: A0A8C0M6T8 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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