Canine EGF Protein 2389

$345.00 – $1,150.00

Summary

Expression: E.coli
Functional: Yes (ELISA)
Amino Acid Range: Asn973-Arg1024

SKU: 2389parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9BEA0
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	The epidermal growth factor (EGF) family of peptides encodes several proteins that can function as growth factors. The EGF-like peptides, with the exception of proteins of the EGF-CFC subfamily, bind and activate tyrosine kinase receptors that belong to the erbB family.
molecular weight	The protein has a predicted MW of 13.61 kDa. The protein migrates to 16-22 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Canine EGF Protein 2389

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The epidermal growth factor (EGF) family of peptides encodes several proteins that can function as growth factors. The EGF-like peptides, with the exception of proteins of the EGF-CFC subfamily, bind and activate tyrosine kinase receptors that belong to the erbB family.
Protein names Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor]
Gene names EGF,EGF
Mass 9615Da
Function EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
Subellular location Membrane ; Single-pass type I membrane protein .
Structure Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
Target Relevance information above includes information from UniProt accession: Q9BEA0
The UniProt Consortium

Immobilized Canine EGF, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human EGFR, hFc Tag with the EC50 of 4.7ng/ml determined by ELISA (QC Test).

Measured in a cell proliferation assay using Balb 3T3 mouse embryonic fibroblasts. The EC50 for this effect is typically 0.5 - 3 ng/mL.

The purity of Canine EGF is greater than 95% as determined by SEC-HPLC.

Canine EGF on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.