Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
express system | E.coli |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE |
background | Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. |
molecular weight | The protein has a predicted MW of 13.68 kDa. The protein migrates to 14-17 kDa under reduced (R) condition and 25-30 kDa under Non reducing (N) condition based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Biotinylated Rat GDF15 Protein (Primary Amine Labeling) 7113
$600.00 – $2,000.00
Summary
- Expression: E.coli
- Functional: Yes (ELISA)
- Amino Acid Range: Ser189-Ala303
Biotinylated Rat GDF15 Protein (Primary Amine Labeling) 7113
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. |
Protein names Growth/differentiation factor 15 (GDF-15) |
Gene names Gdf15,Gdf15 Sbf |
Protein family TGF-beta family |
Mass 10116Da |
Function Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite (PubMed:28846099, PubMed:28953886, PubMed:31928886, PubMed:34187898, PubMed:37060902). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846099, PubMed:28953886, PubMed:37060902). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:37060902). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:37060902). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (By similarity). Responsible for the risk of nausea during pregnancy: high levels of GDF15 during pregnancy, mostly originating from embryos, are associated with increased nausea (By similarity). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, females with naturally high level of GDF15 being less susceptible to nausea than female rats with low levels of GDF15 before pregnancy (By similarity). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (By similarity). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). |
Subellular location Secreted. Note=Secreted in the plasma. |
Tissues Detected in plasma (at protein level). |
Structure Homodimer; disulfide-linked (By similarity). Interacts with GFRAL and RET; ligand of GFRAL, which mediates GDF15 internalization and cellular signaling through interaction with RET via the formation of a 2:2:2 ternary complex composed of GDF15, GFRAL and RET (By similarity). |
Target Relevance information above includes information from UniProt accession: Q9Z0J6 |
The UniProt Consortium |
Publications
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