Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
express system | HEK293 |
product tag | C-His-Avi |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. |
molecular weight | The protein has a predicted MW of 22.37 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein 2153
$525.00 – $1,750.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Leu117-Gly298
Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein 2153
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. |
Protein names Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD antigen CD87) |
Gene names Plaur,Plaur |
Mass 10090Da |
Function Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. |
Subellular location [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted . |
Tissues Expressed in angiogenic endothelial cells (at protein level). |
Structure Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity). Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (By similarity). |
Target Relevance information above includes information from UniProt accession: P35456 |
The UniProt Consortium |
Publications
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