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Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein 2153

$525.00$1,750.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Leu117-Gly298
SKU: 2153parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR.

molecular weight

The protein has a predicted MW of 22.37 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein 2153

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR.
Protein names
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD antigen CD87)
Gene names
Plaur,Plaur
Mass
10090Da
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
Subellular location
[Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .
Tissues
Expressed in angiogenic endothelial cells (at protein level).
Structure
Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity). Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (By similarity).
Target Relevance information above includes information from UniProt accession: P35456
The UniProt Consortium

HPLC of Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein
The purity of Biotinylated Mouse uPAR Domain (2+3) is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Biotinylated Mouse uPAR/PLAUR Domain (2+3) Protein
Biotinylated Mouse uPAR Domain (2+3) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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