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Biotinylated Human Oncostatin M/OSM Protein 4756

$525.00$1,750.00

Summary

  • Expression: HEK293
  • Binding assay: Yes (SPR)
  • Amino Acid Range: Ala26-Arg221
Weight1 lbs
Dimensions9 × 5 × 2 in
product tag

C-His-Avi, also biotinylated

Biotinylated Human Oncostatin M/OSM Protein 4756

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Protein names
Oncostatin-M (OSM)
Gene names
OSM,OSM
Protein family
LIF/OSM family
Mass
9606Da
Function
FUNCTION: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:1542792, ECO:0000269|PubMed:1542793}.
Subellular location
SUBCELLULAR LOCATION: Secreted.
Post-translational modification
PTM: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. {ECO:0000269|PubMed:2325640}.
Target Relevance information above includes information from UniProt accession : P13725
The UniProt Consortium

Data

SPR with Biotinylated Human Oncostatin M/OSM Protein
Human LIF R, His Tag immobilized on CM5 Chip can bind Biotinylated Human Oncostatin M, His Tag with an affinity constant of 0.94 µM as determined in SPR assay (Biacore T200).
HPLC of Biotinylated Human Oncostatin M/OSM Protein
The purity of Biotinylated Oncostatin M is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Biotinylated Human Oncostatin M/OSM Protein
Biotinylated Oncostatin M on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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