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Biotinylated Human Nectin-4 Protein IgV Domain 4810

$525.00$1,750.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gly32-Leu146
Weight1 lbs
Dimensions9 × 5 × 2 in
product tag

C-His-Avi, also biotinylated

Biotinylated Human Nectin-4 Protein IgV Domain 4810

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.
Protein names
Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
Gene names
NECTIN4,NECTIN4 LNIR PRR4 PVRL4
Protein family
Nectin family
Mass
9606Da
Function
FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; SUBCELLULAR LOCATION: [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).
Tissues
TISSUE SPECIFICITY: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. {ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:17474988}.
Structure
SUBUNIT: Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN. {ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:12011057, ECO:0000269|PubMed:22902367}.; SUBUNIT: (Microbial infection) Interacts with measles virus Hemagglutinin protein (PubMed:22048310, PubMed:23202587). {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.
Post-translational modification
PTM: The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. {ECO:0000269|PubMed:15784625}.
Target Relevance information above includes information from UniProt accession : Q96NY8
The UniProt Consortium

Data

ELISA with Biotinylated Human Nectin-4 Protein IgV Domain
Immobilized Anti-Nectin-4 Antibody, hFc Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human Nectin-4 IgV Domain, His Tag with the EC50 of 30.9ng/ml determined by ELISA.
HPLC of Biotinylated Human Nectin-4 Protein IgV Domain
The purity of Biotinylated Human Nectin-4 IgV Domain is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Biotinylated Human Nectin-4 Protein IgV Domain
Biotinylated Human Nectin-4 IgV Domain on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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