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Biotinylated Human MSLN/Mesothelin Protein 5204



  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Glu296-Gly580
Weight1 lbs
Dimensions9 × 5 × 2 in
product tag

C-His-Avi, also biotinylated

Biotinylated Human MSLN/Mesothelin Protein 5204

Size and concentration
100, 500µg and lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
> 95% as determined by Tris-Bis PAGE
target relevance
Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.A knockout mouse line that lacks mesothelin reproduces and develops normally.
Protein names
Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
Gene names
Protein family
Mesothelin family
FUNCTION: Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Subellular location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
TISSUE SPECIFICITY: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:7665620}.
SUBUNIT: Interacts with MUC16. {ECO:0000269|PubMed:14676194, ECO:0000269|PubMed:22787150}.
Post-translational modification
PTM: Both MPF and the cleaved form of mesothelin are N-glycosylated. {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:8288629, ECO:0000269|PubMed:8552591}.; PTM: Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. {ECO:0000269|PubMed:8552591}.
Target Relevance information above includes information from UniProt accession : Q13421
The UniProt Consortium


ELISA with Biotinylated Human MSLN/Mesothelin Protein
Immobilized Anti-MSLN Antibody at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human MSLN, His Tag with the EC50 of 13.7ng/ml determined by ELISA.
HPLC of Biotinylated Human MSLN/Mesothelin Protein
The purity of Biotinylated Human MSLN was greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Biotinylated Human MSLN/Mesothelin Protein
Biotinylated Human MSLN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.


Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.



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