no metadatahttps://benchmarkantibodies.com/product/biotinylated-human-cd30-tnfrsf8-protein-4584/
Skip to content

Biotinylated Human CD30/TNFRSF8 Protein 4584

$525.00$1,750.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Phe19-Lys379
SKU: 4584parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
product tag

C-His-Avi, also biotinylated

Biotinylated Human CD30/TNFRSF8 Protein 4584

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions. CD30 expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs).
Protein names
Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
Gene names
TNFRSF8,TNFRSF8 CD30 D1S166E
Protein family
TNFR8 family
Mass
9606Da
Function
FUNCTION: Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:8391931, ECO:0000269|PubMed:8999898}.
Subellular location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}.
Tissues
TISSUE SPECIFICITY: [Isoform 2]: Detected in alveolar macrophages (at protein level). {ECO:0000269|PubMed:8839832}.
Structure
SUBUNIT: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:10518213, ECO:0000269|PubMed:8627180, ECO:0000269|PubMed:8999898, ECO:0000269|PubMed:9168896, ECO:0000269|PubMed:9511754}.
Post-translational modification
PTM: Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832). {ECO:0000269|PubMed:8839832, ECO:0000305}.
Target Relevance information above includes information from UniProt accession : P28908
The UniProt Consortium

Data

ELISA with Biotinylated Human CD30/TNFRSF8 Protein
Immobilized Anti-CD30 Antibody, hFc Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human CD30, His Tag with the EC50 of 11.5ng/ml determined by ELISA (QC Test).
ELISA with Biotinylated Human CD30/TNFRSF8 Protein
Immobilized Human CD30 Ligand, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human CD30, His Tag with the EC50 of 27.1ng/ml determined by ELISA.
HPLC of Biotinylated Human CD30/TNFRSF8 Protein
The purity of Biotinylated CD30 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Biotinylated Human CD30/TNFRSF8 Protein
Biotinylated CD30 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product

Documents

#
No results found

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.