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Biotinylated Human B7-H2/ICOSLG Protein 4764

$525.00$1,750.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Asp19-Ser258
SKU: 4764parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
product tag

C-His-Avi, also biotinylated

Biotinylated Human B7-H2/ICOSLG Protein 4764

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Protein names
ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
Gene names
ICOSLG,ICOSLG B7H2 B7RP1 ICOSL KIAA0653
Protein family
Immunoglobulin superfamily, BTN/MOG family
Mass
9606Da
Function
FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). {ECO:0000250}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11007762}; Single-pass type I membrane protein {ECO:0000255}.
Tissues
TISSUE SPECIFICITY: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}.
Structure
SUBUNIT: Interacts with CTLA4 (in vitro). {ECO:0000269|PubMed:28484017}.
Target Relevance information above includes information from UniProt accession : O75144
The UniProt Consortium

Data

ELISA with Biotinylated Human B7-H2/ICOSLG Protein
Immobilized Human ICOS (C136S,C137S), His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human B7-H2, His Tag with the EC50 of 25.1ng/ml determined by ELISA.
SDS-PAGE gel of Biotinylated Human B7-H2/ICOSLG Protein
Biotinylated Human B7-H2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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