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CCL3 (MIP-1a)
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
| target | type | reactivity | applications | ||||
|---|---|---|---|---|---|---|---|
| 8017 | Biotininylated CCL3 (MIP-1a) | human | |||||
| 6004 | CCL3 (MIP-1a) | human | |||||
Migration assay with [8017] : Migration Assay: Cells expressing recombinant CCR5 were assayed for migration through a transwell filter at various concentrations of WT or Biotinylated MIP-1α. Responses are expressed as the % of total input cells (Blue: wild type; Red: biotinylated).
