Actin Smooth Muscle Sma

Actin Smooth Muscle Sma

: Smooth Muscle Actin (SMA) is the definitive intermediate filament protein found in smooth muscle cells and myofibroblasts. Its role in regulating cellular contractility makes it a cornerstone marker for any lesion involving smooth muscle differentiation. Aberrant expression or modification of Actin Smooth Muscle Sma is often implicated in the pathology of key diseases, making it a crucial biomarker and a prime focus for translational research and drug development.

The diagnostic utility of Immunohistochemistry (IHC) for Actin Smooth Muscle Sma is unparalleled in its specific application. SMA IHC is vital for the differential diagnosis of spindle cell lesions. It is routinely used to confirm the smooth muscle origin of neoplasms, notably in distinguishing leiomyomas from leiomyosarcomas. Precise localization helps pathologists delineate the extent of tumor invasion and determine malignancy potential, directly impacting patient prognosis and treatment. Accurate analysis of expression and localization using highly specific monoclonal antibodies allows researchers and pathologists to achieve superior diagnostic resolution and drive better patient stratification.